Proteasome inhibitors in Multiple Myeloma

Prof. Nikhil Munshi, MD from Dana-Farber Cancer Institute, Boston, MA discusses the role of proteasome inhibitors in the treatment of multiple myeloma (MM). the function of proteasomes is to remove damaged or unwanted proteins from the environment. Inhibiting these complexes results in a toxic increase of proteins inside the cell, and subsequent death. This is suitable for multiple myeloma as proteasome inhibitors have multiple mechanisms of action, allowing it to target multiple types of cells in MM. Recorded at the annual meeting of the European Society for Blood and Marrow Transplantation (EBMT) in Marseille, France.